Neurobiology of Disease Synaptic Circuit Abnormalities of Motor-Frontal Layer 2/3 Pyramidal Neurons in an RNA Interference Model of Methyl-CpG-Binding Protein 2 Deficiency
نویسندگان
چکیده
Lydia Wood,1 Noah W. Gray,2 Zhaolan Zhou,3 Michael E. Greenberg,4,5 and Gordon M. G. Shepherd1 1Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, 60611, 2Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, 3Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, 4Neurobiology Program, Children’s Hospital Boston, Boston, Massachusetts 02115, and 5Departments of Neurology and Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
منابع مشابه
Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency.
Rett syndrome, an autism spectrum disorder with prominent motor and cognitive features, results from mutations in the gene for methyl-CpG-binding protein 2 (MeCP2). Here, to identify cortical circuit abnormalities that are specifically associated with MeCP2 deficiency, we used glutamate uncaging and laser scanning photostimulation to survey intracortical networks in mouse brain slices containin...
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تاریخ انتشار 2009